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49ers vs. Seahawks Odds & Betting Predictions - September 7, 2025

49ers at Seahawks

8:05 pm • FOX
Stream Live on SiriusXM - Free 3 Month Offer

San Francisco 49ers

0-0
@

Seattle Seahawks

0-0

49ers at Seahawks Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
49ers
0-0
-1.5
-2-110
o43.5-106
-130
Seahawks
0-0
u45.5
+2-110
u43.5-115
+110
location pinSunday 8:05 p.m.
September 07, 2025
Lumen FieldSeattle
thermometer image68°Fahrenheit
rain image0%Rain
wind image7Wind
49ers vs. Seahawks Expert Picks
Chris Gimino
Chris Gimino
Last 30d: 2-0-0 (+3.3u)
B.Purdy u32.5 Pass Att-115
1u
💰🦡 Jake
💰🦡 Jake
Last 30d: 74-88-7 (-14.8u)
SF -0.5 (1H)-110
1.1u
Ryan Sura
Ryan Sura
Last 30d: 39-38-4 (-1.5u)
G.Kittle o59.5 Rec Yds-110
1.1u
Royals Props
Royals Props
Last 30d: 4-6-0 (-3.1u)
G.Kittle o60.5 Rec Yds-125
1.25u
Fanatics
Top Shelf Action 🥃
Top Shelf Action 🥃
Last 30d: 97-101-2 (-9.7u)
SEA +1.5-105
1.05u
Early season divisional underdogs Overall: 130-66-6,66% (ROI:27%)

49ers vs. Seahawks Previews & Analysis

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49ers vs. Seahawks Props

Prop Projections

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Prop Odds Comparison

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Line Movement Tracker

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49ers vs. Seahawks Public Betting Percentages

Away Logo

49ers

Public

Home Logo

Seahawks

51%

Bets%

49%

Money%

NFL Public Betting Right Arrow

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Seahawks		N/AN/AN/AN/AN/A
49ers		N/AN/AN/AN/AN/A

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Seahawks		N/AN/AN/AN/AN/A
49ers		N/AN/AN/AN/AN/A

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Seahawks		N/AN/AN/AN/AN/A
49ers		N/AN/AN/AN/AN/A

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Aug 23rd@GBL 7-20+3 LU 37.5GB +140
Aug 16thKCW 33-16-5 WO 38SEA -220
Aug 8thLVW 23-23+5.5 WO 36.5LV +200
Jan 5th@LAW 30-25-7.5 LO 38.5SEA -350
Dec 27th@CHIW 6-3-4.5 LU 42.5SEA -225

49ers vs. Seahawks Injury Updates

49ers Injuries

  • Demarcus Robinson
    WR

    Robinson is out with suspension

    Out

  • Brandon Aiyuk
    WR

    Aiyuk is out with knee

    Out

  • Jacob Cowing
    WR

    Cowing is out with hamstring

    Out

Seahawks Injuries

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    Player Stats
    • passing yards
      player logo
      -
      4320
      pyds
    • passing touchdowns
      player logo
      -
      21
      ptd
    • rushing yards
      Kenneth Walker logo
      Kenneth Walker
      573
      ryds
    • rushing touchdowns
      Zach Charbonnet logo
      Zach Charbonnet
      8
      rtd
    Depth Charts
    Right Arrow
    Starter2ND3RD4TH
    QBSam DarnoldDrew LockJalen Milroe
    RBKenneth WalkerZach CharbonnetGeorge HolaniDamien MartinezJacardia Wright
    WRCooper KuppDareke Young
    TEAJ BarnerElijah ArroyoEric SaubertNick Kallerup
    LTCharles CrossAmari Kight
    LGGrey ZabelBryce Cabeldue
    COlu OluwatimiJalen SundellFederico Maranges
    RGAnthony BradfordChristian HaynesMason Richman
    RTAbraham LucasJosh Jones
    LDEDeMarcus LawrenceDerick HallJared IveyConnor O'Toole
    RDELeonard WilliamsMike MorrisJ.R. Singleton
    WLBTyrice KnightPatrick O'ConnellJamie Sheriff
    MLBErnest JonesDrake Thomas
    LCBJosh JobeNehemiah PritchettShemar Jean-Charles
    SSJulian LoveNick EmmanworiJerrick Reed
    FSCoby BryantD'Anthony BellTy Okada
    RCBRiq WoolenShaquill Griffin
    PMichael Dickson
    HMichael Dickson
    PRTory Horton
    KRTory HortonZach Charbonnet
    LSChris Stoll
    NBDevon Witherspoon
    LOLBUchenna NwosuBoye Mafe
    NTByron MurphyJohnathan HankinsBrandon PiliQuinton Bohanna
    KJason Myers
    FBRobbie OuztsBrady Russell
    DTJarran ReedRylie Mills
    LWRJaxon Smith-NjigbaJake BoboCody WhiteTyrone Broden
    RWRTory HortonRicky White
    ROLBJamie SheriffConnor O'Toole

    49ers vs. Seahawks Odds Comparison

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    49ers at Seahawks Team Totals

    MatchupOverUnder
    49ers
    0-0
    N/A
    N/A
    Seahawks
    0-0
    N/A
    N/A